BRL.8988 (talampicillin), a well-absorbed oral form of ampicillin.
نویسندگان
چکیده
The phthalidyl ester (BRL.8988, talampicillin) of ampicillin gave serum levels in man two and a half times those obtained with ampicillin itself.
منابع مشابه
Triple crossover study on absorption and excretion of ampicillin, talampicillin, and amoxycillin.
Talampicillin and amoxycillin were shown to be absorbed twice as well as ampicillin in a triple crossover experiment.
متن کاملTalampicillin: a new derivative of ampicillin.
Talampicillin is a thiazolide carboxylic ester of ampicillin and is hydrolysed in the intestinal mucosa to release free ampicillin. The mean peak serum concentration of ampicillin occurred one hour after a dose of talampicillin and was about twice that attained by an equivalent dose of ampicillin. The presence of food in the stomach reduced and delayed the peak blood levels but did not affect t...
متن کاملSingle oral dose of 1-5g. talampicillin in the treatment of gonorrhoea.
81 patients have been treated with single oral doses of 1-5 g. (6 tablets) of talampicillin without probenecid. The failure rate amongst those followed was only 4-2 per cent. No side-effects were reported. These results were superior to those obtained with 2-0g. or equivalent of ampicillin, amoxycillin, or pivampicillin with probenecid. Talampicillin is thus the most potent ampicillin-like anti...
متن کاملTreatment of uncomplicated gonorrhoea in women with talampicillin in a single oral 1.5 g dose.
Four hundred and sixty women with uncomplicated gonorrhea were treated with a single oral dose of 1.5 g talampicillin. The success rate among those who attended for at least one follow-up examination after treatment was 99.14%. The antibiotic was well tolerated and no side effects were reported. Talampicillin given under supervision has proved to be the most effective and safest treatment in th...
متن کاملAmpicillin concentrations in human dental granuloma after a single oral administration of talampicillin.
Ampicillin concentrations in human serum and dental granulomas of 31 patients were determined after a single oral dose of talampicillin (equivalent to 500 mg of ampicillin) was administered to each. The specimens were taken at 1.5, 2.0, 2.5, 3.0, and 3.5 h after the administration of talampicillin. The mean peak ampicillin concentrations in serum and dental granulomas occurred at identical time...
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ورودعنوان ژورنال:
- Antimicrobial agents and chemotherapy
دوره 5 6 شماره
صفحات -
تاریخ انتشار 1974